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The evolving landscape of noncanonical functions of metabolic enzymes in cancer and other pathologies
Its metabolic functions include: Enhanced immune function Elimination of toxins Elimination of carcinogens Antioxidant cell protection Protections against ionizing radiation DNA synthesis and repair Protein synthesis Prostaglandin synthesis Amino acid transport Enzyme activation and regulation These functions can be summarized into three general categories: 1
and Allison, C
Badenhorst T, Svirskis D, Merrilees M, et al
We observed robust inhibition of p70S6K levels in GPX4 knockdown cells compared to non-targeted cells (Fig
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