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In animals, SGLT2 inhibitors cause dilatation of the renal pelvis and tubules of the kidney when used during the second and third trimester and additionally a relatively large number of unfavorable human pregnancy outcomes are found in humans

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There were 2 large human trials with 117 and 320 patients each, but neither showed any benefits after 7-10 days of administration

One trial found that rifaximin was effective and safe to repeat in IBS-D patients that relapsed after an initial effective treatment (Lembo et al., 2016b)

10.1152/ajpgi.00400.2007 Am