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In summary, ceramides can be synthesized in de novo and salvage pathways ( Figure 1 )

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Gastrointestinal distressnausea, vomiting, constipationis most frequent, especially early on

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The primary outcomes of these trials were 3-point major adverse cardiovascular event (3-MACE) and the studies have together provided a wealth of data that, amongst others, have changed clinical guidelines

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But it aligns with the general principle that slower escalation produces fewer side effects across all categories

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Are 80 years of age or older and have not had your kidney function tested

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