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10.3390/ijms23094605 92 CrileG
In a preferred aspect of present invention, such side-chain protecting groups are specified per individual amino acid occurring in the relevant GLP-1 analogue sequence, as follows: the arginine (Arg) guanidinium group is preferably protected by a protecting group selected from the group consisting of methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr), 2, 2, 5,7,8- pentamethylchromanyl-6-sulfonyl (Pmc) and 2,2,4,6,7-pentamethyl-dihydrobenzofuran-5- sulfonyl (Pbf), all removable in acidic conditions
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