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Oxidative stress plays a key role in the pathogenesis of asthma, which is why redox biomarkers could have considerable diagnostic potential in asthma ( Table 1 )

Pregnancy and breastfeeding require clinician guidance Because safety evidence is limited in pregnancy and breastfeeding, those situations should be handled conservatively and individually

Accurate assessment of the scope of this phenomenon remains challenging due to its predominantly clandestine nature, frequent polypharmacy, and the widespread availability of unregulated substances of uncertain composition and purity

speculation includes endogenous IGF-1 axis suppression or downstream insulin/glucose dynamics

Failure to eliminate dysfunctional mitochondria leads to the accumulation of mitochondrial ROS and the release of immunogenic mtDNA, both of which act as DAMPs that activate innate immune pathways, including the NLRP3 inflammasome and type I interferon (IFN-I) signaling