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When a man on a compounded preparation does not respond, there are now three candidate explanations rather than one: he is the wrong patient for the mechanism, the dose is wrong for him, or the preparation is not delivering what the label claims
Menstrual changes during treatment may include longer or shorter cycles, heavier or lighter bleeding, or missed periods, typically related to the rate and magnitude of weight loss
The mechanisms involved changes in short-chain fatty acid production, particularly acetic acid, which has been shown to promote circulating levels of GLP-1 and PYY (peptide YY, another satiety hormone)
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