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By inhibiting NNMT, the body maintains higher NAD levels, which in turn activate SIRT1, a longevity-associated gene, which may improve mitochondrial activity, fat oxidation, insulin sensitivity, and by overall energy balance

Dose ranges are often species- and model-dependent, with rodent studies using body-weight-normalized doses (mcg/kg or mg/kg) that may be substantially different from the fixed doses used in primate or pharmacokinetic models

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