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Interestingly, this effect was mediated by the release of CCK and GLP-1 and subsequent activation of their receptors, possibly on VANs (see Hormonal gut-brain signaling section)
What does this mean for practice right now
Major medical organizations including the American College of Obstetricians and Gynecologists have not issued absolute contraindications against GLP-1 medications during breastfeeding, but they emphasize the importance of individualized medical judgment
It is unclear if the increased risk of NAION is specific to semaglutide or also true of other GLP-1 receptor agonist drugs, the study authors wrote in their paper
Pro: Taking a pill or using a sublingual troche is very easy
