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In a vote of regulatory confidence, the FDA granted fast-track regulatory designation to tau antibodies from Bristol Myers Squibb (BMS-986446) and Eisai (etalanetug) late last year

5-Amino-1MQ instead removes a drain on that route: by inhibiting NNMT it prevents nicotinamide from being methylated to 1-methylnicotinamide, leaving it available for NAMPT and the salvage pathway, and simultaneously spares the S-adenosyl-L-methionine that the methylation would have consumed

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