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GLP-1 is a 30-amino acid peptide hormone produced by differential post-translational processing of the proglucagon precursor protein by prohormone convertase 1/3 (PCSK1) in intestinal L-cells and in neurons of the nucleus tractus solitarii (NTS) in the brainstem

Thus, GLP-1RA mediates inflammation to prevent formation of neurotoxic astrocytes which cause RGC death

Kidney outcomes associated with SGLT2 inhibitors versus other glucose-lowering drugs in real-world clinical practice: The Japan Chronic Kidney Disease Database

It has been hypothesized that the peptide might modulate cellular stress responses and promote the maintenance of cellular function during aging