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Start your intake What the Long-Term Clinical Data Actually Shows The largest long-term semaglutide trial, SUSTAIN-5, tracked patients for 230 weeks (over 4 years) and found that gastrointestinal side effectsnausea, vomiting, constipationwere most common during dose escalation phases but declined significantly once patients stabilized on their maintenance dose

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Cardiovascular Outcomes Trial of Semaglutide in Patients with Type 2 Diabetes Mellitus SUSTAIN 6 (NCT01720446) was a 104-week, double-blind trial in which 3,297 patients with type 2 diabetes and high risk of cardiovascular events were randomized to semaglutide 0.5 mg once weekly, semaglutide 1 mg once weekly, or placebo in addition to standard-of-care