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59 Although several DHODH inhibitors have been clinically evaluated, none have received approval for cancer treatment due to insufficient single-agent effectivity
Persistent ROS generation or electrophilic stress can oxidize GSH to GSSG more rapidly than it is reduced, thereby depleting the reduced thiol pool
Code availability The analytic code is available at Change history 31 January 2025 A Correction to this paper has been published: References Pfeffer, M
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