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D., Hansen, T., & Bain, S

IGF-1 facilitates extinction of conditioned fear [PMID: 33792539] Laboratory literature summary: IGF-1 facilitates extinction of conditioned fear

340 Understanding the role of insulin signaling and insulin resistance in peripheral nerves is essential for developing targeted therapies for DPN

1 As summarized in this review, resistance is not solely dictated by tumor-intrinsic genetic alterations but is shaped by a dynamic interplay among clonal evolution, signaling rewiring, epigenetic remodeling, altered DNA damage repair, metabolic adaptation, dysregulated cell death, TCP, microenvironmental remodeling, and hostmicrobetumor interactions