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Its advantages in overcoming drug resistance are: 1) Oral formulations are delivered through albumin binding or nanocarriers to avoid insufficient uptake caused by low hENT1 expression (D et al., 2025), and in pancreatic cancer models, the efficacy is 30% higher than that of intravenous formulations
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Never self-medicate, as long-term side effects remain unknown
GCGR/GLP-1R agonist: OR: 0.15, 95%CI: 0.040.56, P = 4.68 10 3
Mental health concerns, including anxiety and depression, especially with semaglutide, were also notable but occurred less often than GI symptoms, with Wegovy showing the highest depression mention rate
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