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Gently massage the cream in circular motions until fully absorbed, and for optimal results, use it twice daily, in the morning and evening, following your regular skincare routine

doi: 10.1007/s13311-018-0666-8 109

To account for potential dropout of up to 20%, a total of 24 subjects were planned for active treatment, and 12 subjects were planned for treatment with placebo (total for both placebo doses), leading to a total number of 36 subjects planned to start in the trial