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Noteworthy, we did not observe any clear localization of H2AX in the telomeres across age groups, suggesting that the signal of DNA DSB in old killifish kidney marrows might not be specifically linked to telomeric regions (Extended Data Fig

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siRNA transfections were performed using Lipofectamine 2000 and ON-TARGETplus Human SMARTpool siRNAs (Dharmacon) against TYMS and a scrambled control pool, according to the manufacturers instructions

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Currently, the SURPASS-CVOT trial is evaluating the impact of dulaglutide and tirzepatide on cardiovascular events in patients with T2D (NCT04255433)