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Tirzepatide : Has shown superior efficacy in reducing blood sugar levels and body weight compared to Semaglutide in clinical trials
PMID: 17200221, DOI: 10.7326/0003-4819-146-1-200701020-00008
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However, N-terminal modifications, such as N-acetylation, D-norleucine substitution, or replacement with -aminobutyric acid (GABA), dramatically elongated the peptides half-lives
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