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Although found tethered to the apical (luminal) membranes of capillary endothelial cells, the endothelial cells themselves do not synthesize the enzyme

They are produced by the dendritic, octopus-like melanocytes, seen between the epithelial cells situated closest to the epithelium/connective tissue border

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Until we find things that are better, I suspect that the GLP-1 agonists or combination GLP-1 and GIP [glucose-dependent insulinotropic polypeptide] agonists, like tirzepatide, are likely to be the person's best option

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