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Because AOD-9604 works peripherally on fat tissue through beta-3 adrenergic receptors without affecting central appetite pathways, there is no adaptation of hunger-regulating systems and therefore no rebound effect when stopping

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This rigorous methodology minimizes bias and allows for accurate attribution of adverse effects to the intervention rather than background health conditions or placebo effects

The CD36 encoded protein was originally identified a platelet receptor for thrombospondin and mutations in the CD36 gene are associated with platelet glycoprotein deficiency

PMC Sikiric P, et al