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DEGs were identified using the DESeq2 R package, and results were visualized as a volcano plot using the ggplot2 R package ( Metabolic genes were defined based on a curated list 6,40

Viral-mediated delivery of HSP72 or HSP60 has demonstrated efficacy in preclinical models, improving metabolic parameters and preventing disease progression

overexpressed miR-340-5p in the myocardium by direct myocardial injection of AVV-9 containing miR-340-5p precursor, which targeted inhibition of MyD88 and thus restored declining GSH levels, alleviated insult of cardiac function and oxidative injury induced by sepsis in the hearts of mice [253]

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