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(Frontiers in Pharmacology, 2022) reported pharmacokinetics and tissue distribution in rats and dogs, including a rapid plasma half-life under 30 minutes after IM or IV dosing

however, sex, rurality, and SVI were not

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Also, our results about the gene expression analyses revealed that either LC or LCLN greatly upregulated the expression of 3-HSD , StAR and CYP11A1 genes, thereby significantly reducing the deleterious effects of ATZ on decreasing such hormones

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