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GLP-1RAs and co-agonists have shown promising outcomes in the clinical management of MASLD

Oral GLP-1 formulations are adding manufacturing complexity in a different dimension: on December 22, 2025, the FDA approved Novo Nordisk's oral Wegovy 25 mg as the first oral GLP-1 therapy for weight loss, bringing with it the manufacturing requirements of oral solid dosage pharmaceutical production at commercial scale, a fundamentally different infrastructure challenge from parenteral peptide API synthesis

McCulloch uses L-carnitine for patients who are wanting to support their mitochondrial health, have insulin resistance, or need help with brain antioxidant status

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