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Description

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Like all GLP-1 agonists, tirzepatide slows gastric emptying, which can modestly delay absorption of oral medications

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Cell 120:48395, PMID: 15734681 Bertout JA, Patel SA, Simon MC (2008) The impact of O2 availability on human cancer

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Receptor endocytosis, an intermediate step toward downregulation, is also necessary for resensitization via dephosphorylation and recycling 11, thus, totally inhibiting endocytosis will likely result in reduced signaling as surface receptors become desensitized via -arrestin recruitment

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