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BPC-157 work centres on local angiogenic signalling, with Hsieh and colleagues (J Mol Med, 2017) reporting VEGFR2 upregulation and internalisation in human endothelial cells, and Chang and colleagues (J Appl Physiol, 2011) reporting increased focal adhesion kinase and paxillin phosphorylation in cultured rat tendon fibroblasts

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Indeed, the liver has been reported to need a maximal synthesis of GSH for detoxifying exogenous xenobiotics, such as acetaminophen 75,76

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