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PI3P facilitates the recruitment of Atg proteins to the developing autophagic membrane, promoting vesicle formation and expansion

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Thus, establishing whether the in vivo effect of leptin on macrophages favors atherogenesis in humans is of clinical interest, especially in diabetic patients who have elevated plasma leptin levels and demonstrate enhanced proatherogenic cytokines secretion by macrophages (e.g., tumor necrosis factor-

No great, actually