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The modifications focused on the 1,4-dioxin moiety and the isopropyl acetate bond as the 2,3-dihydrobenzofuran core and benzyl ring of the 2,3-dihydrobenzodioxin groups were crucial for preserving hydrophobic contacts with the P-clamp residues
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GSH levels, turnover rates, and/or oxidation state can be compromised by inherited or acquired defects in the enzymes, transporters, signaling molecules, or transcription factors that are involved in its homeostasis, or from exposure to reactive chemicals or metabolic intermediates
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