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Finally, 28 articles were aligned with the study objectives and were considered eligible for this SR ( Figure 1
We introduced a Cys-to-Arg point mutation (C224R) based on a previous report that Cys-to-Ser mutation, but not Cys-to-Arg, increases interaction with ubiquitin 39
Elafibranor is a dual peroxisome proliferator-activated receptor (PPAR)-/ agonist and as such has effects on the regulation of metabolic homeostasis, inflammation, cellular growth, and differentiation.86 PPAR- is a regulator of fatty acid transport and a major inducer of -oxidation of fatty acids
A meta-analysis of ten studies examining the effects of LCDs on NAFLD revealed that participants with NAFLD who followed LCDs exhibited a significant reduction in intrahepatic lipid content
A more recent study has also shown that they may be beneficial for weight loss
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