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In that study, the glucose-sensing transcription factor carbohydrate response element binding protein (ChREBP) has been shown to initiate a regulatory program driving an early transcriptional activation of metabolic genes, which is followed by a second wave of transcriptional regulation wherein cell-cycle genes are activated and -cell identity genes are repressed
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The dividers were then removed to allow the test rat to explore the apparatus for another 10 min
However, even in subjects without such obvious neurological and anatomical complications (the uncomplicated cases), the expression of myelin and oligodendrocyte-related proteins, or their mRNAs, can be significantly altered in various brain regions, being particularly prominent in the PFC (Mayfield et al., 2002
