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B12 supplementation is extremely safe with no established upper limit for toxicity

This reluctance is likely to be at least partially attributable to the fact that, until recently, all GLP-1RAs were available as subcutaneous (s.c.) injections, given twice daily (exenatide [13]), once daily (lixisenatide [14] and liraglutide [15]), or once weekly (semaglutide [16], dulaglutide [17], and exenatide extended release [18]), a route that may be less preferable to some patients compared with oral administration [1, 19]

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Published 2015 Jan 10

The goal is a plan you can sustain, since metabolic change is maintained over time rather than achieved in a single visit