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Supplementation with GSH is generally ineffective at increasing cellular glutathione levels because most human cells cannot uptake extracellular GSH due to the lack of the membrane-bound ectoenzyme -glutamyltranspeptidase (-GT) or due to an unfavorable concentration gradient across the cell membrane 10,16
Rhee, T
(2009) Apoptosis and glutathione: beyond an antioxidant, Cell Death Differ
After PSM, our study identified significant differences in transaminase levels, recurrence rates, and mortality after adjuvant chemotherapy between breast cancer patients between GSH group and Non-GSH group, indicating that GSH intake may have adverse effects on chemotherapy outcomes
Clinical evidence and real-world data from three large cardiovascular trials (LEADER, SUSTAIN 6, and PIONEER 6) have also supported the beneficial effect of GLP-1RAs in dementia (Nrgaard et al., 2022)
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