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Maltepe E, Saugstad OD
In patients with pre- existing seizure activity, an increase in seizure frequency and/or severity has been reported
It is hypothesized that LAL activates the positive ARE at 4 kb leading to upregulation of hTERT, whereas at SAL, the nARE predominates control of hTERT transcription resulting in androgen-mediated suppressed hTERT expression
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