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Matrix Metalloproteinases (MMPs) and Their Inhibitors (TIMPs): The balance between MMPs (which break down the ECM) and TIMPs (which inhibit MMPs) is critical for tissue homeostasis

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This in turn activates the JAK2/STAT3 pathway, promoting FAO and thereby driving M2 polarization while enhancing PD-L1-mediated T cell exhaustion (197)