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GLP-1 is released from intestinal L-cells in a biphasic pattern following meal ingestion: an initial early peak within 1015 minutes, driven primarily by neural and endocrine signals from the upper gastrointestinal tract, is followed by a sustained second peak at 3060 minutes driven by direct nutrient contact with L-cells in the distal ileum and colon
Here is what each group achieved at 48 weeks
About 43% on the highest dose reported nausea, for instance, while 33% reported diarrhea
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