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Icariin demonstrates a protective effect against gentamicin-induced ototoxicity in HEI-OC1 cells and cochlear explants through AMPK-SIRT3 signaling cascade activation, thereby offering a novel approach for addressing ototoxicity resulting from aminoglycoside antibiotics (Hu and Ma 2021)
Originally, IV therapy was used mainly in hospitals for patients who were unable to take medications orally, dehydrated or were nutrient deficient
It exists in two states: reduced (GSH) and oxidized (GSSG)
Allantoin: Calms and soothes irritated skin, promoting repair
At higher doses, some concern exists about pro-inflammatory effects: LL-37 can activate NF-kB pathways, potentially worsening certain inflammatory conditions
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