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Phase 2 trials (Jastreboff et al., NEJM, 2023) have shown it to be highly effective for weight reduction in adults with obesity
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That single feature accounts for most of its practical behaviour: it is freely water-soluble, it does not aggregate, it has no conformational state to preserve, and it is supplied as a salt whose counterion is part of what you weigh
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Focus on compound movements
Preclinical data have not shown prominent adverse effects, but human safety data are limited
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