(Source: WeightSherpa, March 2026) ObesityWeek 2025 Real-World Tirzepatide Data Real-world data presented at ObesityWeek 2025 showed over 90% of PCOS patients lost at least 10% of body weight within 10 months on tirzepatide, with a mean weight loss of 18.81% comparable to tirzepatides general SURMOUNT-1 trial results (22.5% at the highest dose)
For further discussion of these and other risks and uncertainties, see Lilly's most recent Form 10-K and Form 10-Q filings with the United States Securities and Exchange Commission
What seems to matter most: What your appetite was like before you started How long you were on treatment Your dose Whether you built healthy habits you can maintain without the medication Should you taper off a GLP-1 or stop cold turkey
If you decide to try polypeptide therapy to assist in weight reduction or if it is suggested to try one to help with diabetes, high cholesterol, fatty liver disease, or visceral adiposity, be mindful of the side effects and address them
16S rRNA amplicon sequencing was used to analyze the gut microbiota in enrolled patients from stool