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High-intensity exercise also increases the production of free radicals

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As shown in Figure 6A , GSH levels decreased to 2540% of control cells after AQ-QI or DEAQ-QI treatment, while the intracellular GSSG concentrations did not increase correspondingly, but decreased to approximately 4580% ( Figure 6B )

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These processes are regulated by S-adenosyl-methionine (SAM) and S-adenosyl-homocysteine (SAH), along with vitamins B6, B9, and B12

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