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doi: 10.1126/science.270.5238.985 160 TivolEABorrielloFSchweitzerANLynchWPBluestoneJASharpeAH

Interestingly, in trajectory 3 after 750 ns, the dynamic ECD moves back toward the TMD and is stabilized in a conformation that forms contacts mainly with ECL1, resembling the closed ECD conformation in the crystal structure

However, when too much everyday stress, lack of sleep, and unhealthy eating all come together, this protective shield becomes overloaded and the entire system is thrown out of balance

Neuropathol Appl Neurobiol