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Pi-Sunyer et al., NEJM (2015)
Model-based analyses provide a quantitative framework to support individualized treatment decisions when direct comparative evidence is unavailable
But compared to the firehose of pharmaceutical GLP-1 agonists, or even the steady stream of dedicated GLP-1 support supplements, the effect is minimal in terms of meaningful weight management outcomes
Getting the mixing right sets the foundation for everything else
The primary risks involve the quality of the drug substances used
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