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The comparisons below draw from separate clinical trials with different designs, durations, and participant populations

These instances of positive evidence notwithstanding, there are a number of challenges that must be overcome related to prebiotic and probiotic interventions, including unresolved mechanisms, conflicting clinical results, and the use of surrogate or subjective study endpoints in clinical trials to date [103]

Several factors influence how these numbers translate to individual expectations

Coverage is not guaranteed, so patients should check their own policy before the consultation if reimbursement is important

It determines whether split dosing is even possible for your situation