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Since then, glucose, glucose derivatives, multivalent glucosides, p -aminophenyl--D-mannopyranoside, mannose-derivatised liposomes, and 2-deoxy-D-glucose derivatives have been employed for glucose transporter-mediated brain targeting [18]
Enzymes in glutamine metabolism GLS is a key enzyme in glutamine catabolism and exists in mammalian cells in two isoforms: GLS1 (or GLS) and GLS2
The fact that the excitatory effect of -Glu-Glu on synaptic transmission was blocked by TTX indicates that it most likely resulted from an indirect mechanism involving first the partial effect on NMDAr leading and second the endogenous synaptic release of glutamate and glycine, in turn activating both AMPAr and NMDAr ( The changes in -Glu-Glu in the extracellular medium may thus reflect the production of GSH by astroglial cells
The clear separation between treatment and placebo groups (5272 vs 9.6 hairs) leaves little room for doubt about efficacy
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