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growth differentiation factor 8) is a muscle protein that primarily inhibits the growth and differentiation of muscle cells
It also flags low-calorie days and prolonged deficits that raise the risk of sarcopenia
With the caveat that this case series includes only four cases, it appears that narrower optic nerve heads may pose a greater risk for semaglutide-associated NAION, potentially independent of systemic risk factors
Dejgaard TF, Frandsen CS, Hansen TS et al (2016) Efficacy and safety of liraglutide for overweight adult patients with type 1 diabetes and insufficient glycaemic control (Lira-1): a randomised, double-blind, placebo-controlled trial
While this is an important limitation, these studies still provide valuable insights into how the peptide behaves biologically
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