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Caspase-independent death of Lebers hereditary optic neuropathy cybrids is driven by energetic failure and mediated by AIF and Endonuclease G
Hsia DS, Grove O, Cefalu WT
Safety in TRIUMPH-1 The safety profile was consistent with incretin-class therapies: Most common AEs (12 mg dose): - Nausea: 42.4% - Diarrhea: 32.0% - Constipation: 26.1% - Vomiting: 25.3% Dysesthesia (a sensory disturbance tingling, numbness) and urinary tract infections were reported in approximately 10% of patients on the highest doses, but were generally mild to moderate and mostly resolved during treatment
Research shows that glutathione levels in the brain decline with age and are significantly reduced in neurodegenerative conditions like Parkinsons and Alzheimers 9
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