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Cell-mediated immunity primarily needs protein antigen degradation in the endocytic vesicles of antigen presenting cells (macrophages, dendritic cells), to be able to present smaller peptides on the cell surface through major histocompatibility complex antigens to activate antigen-specific T cell proliferation
In animal studies, in comparison to a control diet, HFD consumption resulted in increased hepatic IKK--SSG formation, leading to suppressed IKK- activation and subsequent NF-B suppression
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When overwhelmed, it may suffer stress or injury
The primary role of GSTs is to detoxify xenobiotics by catalyzing the nucleophilic attack by GSH on electrophilic carbon, sulfur, or nitrogen atoms of said nonpolar xenobiotic substrates, thereby preventing their interaction with crucial cellular proteins and nucleic acids
