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Short-acting GLP-1RAs, such as exenatide and lixisenatide, have a half-life of 24 h, requiring daily administration once or twice a day

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Participants receiving 12 mg retatrutide showed a -2.02% decrease in HbA1c levels in patients with type 2 diabetes, compared to -0.01% in the control group

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When a patient attempts to engage in physical or cognitive exertion, they demand ATP that simply isn't available, triggering a severe metabolic crash known as post-exertional malaise (PEM)

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Nausea is the single most common complaint, affecting a significant percentage of users especially during dose escalation

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