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Food and Drug Administration 5630 Fishers Lane, Rm 1061, Rockville, MD 20852: Center for Drug Evaluation and Research (2018)

Phenylketonuria (PKU): The orally disintegrating tablet contains a small amount of phenylalanine

It is a tripeptide made up of three amino acids: glutamine, cysteine, and glycine

Little degradation (apparent t1/2 about 10 h) of DSIP to major metabolites, tryptophan (trp) and des-trp DSIP, occurred over the time of the diffusion experiments

GLP-1 therapy may not be appropriate for individuals with: Personal or family history of medullary thyroid cancer MEN2 syndrome Severe gastrointestinal disease History of pancreatitis (case-by-case evaluation) This is why endocrinology-led screening is essential