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If out of control, diabetes has much higher rates of depression
Phase III trials (TRIUMPH 1-4) are ongoing to confirm efficacy and safety in broader populations
Spermidines ability to protect against neurodegeneration has been particularly well-documented
However, these studies were limited by the toxicity of H 2 O 2 and the poor tissue permeability of BxxP, a membrane-impermeant variant of BP required to prevent labeling of intracellular ER and Golgi proteins by surface-targeted HRP 3
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