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Ozempic is a medication classified as a GLP-1 receptor agonist, originally developed to help manage blood sugar levels in individuals with type 2 diabetes
The safety profile showed modestly elevated rates of overall side effects and drug-attributable side effect in the efinopegdutide cohort relative to semaglutide, attributable predominantly to a higher frequency of gastrointestinal manifestations [52]
It is important to bear in mind that IGF-1 serum concentration is 100-fold greater than insulin, however when bound to IGFBPs its biological activity is modulated and in its free-unbound form presents different effects [99, 157]
doi: 10.1201/CRCEXEPHYSIO 302 JammesYSteinbergJGDelliauxSBrgeonF
Ferenci P, Lockwood A, Mullen K, et al
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