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To inactivate LS GLP-1R neurons, we injected AAV expressing double-floxed EGFP and TeNT (AAV-DIO-EGFP-2A-TeNT) into the bilateral LS of GLP-1R-ires-Cre mice to achieve specific expression of EGFP-2A-TeNT in LS GLP-1R neurons (Figure 3A and Supplemental Figure 6C)
Once the levels become low, pigmentation, unbalanced tone, dullness, and premature ageing are more pronounced
Heart Fail Clin (2020) 16:2331
They enrolled adults with obesity or overweight, ran for 72 weeks, and used change in body weight as the primary endpoint
Nature 575 , 688692 (2019)
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