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Furthermore, therapeutic agents targeting mitochondrial enzymes such as SHMT2, PDH, and CPT1A remain largely in preclinical or early-phase clinical development, with limited data available on optimal delivery strategies, pharmacokinetics, and safety profiles [24]
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Microglial cells in culture express a prominent glutathione system for the defense against reactive oxygen species
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PKA enhances the acute insulin response leading to the restoration of glucose control
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